Abstract
During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged. We analyzed 78 isolates from the 2013–2017 epidemic and documented continued expansion of Prn-negative ptxP3 B. pertussis strains. We also detected a filamentous hemagglutinin-negative and Prn-negative B. pertussis isolate.
Highlights
Pertussis remains a major public health concern. In many industrialized countries, including Australia, whole-cell vaccine was replaced by the less reactogenic acellular vaccine (ACV)
Despite high vaccination coverage, pertussis remains a major public health concern
The Study We sequenced 78 B. pertussis isolates (Appendix 1 Table 1) from New South Wales (NSW) (17/78 [21.8%]) and Western Australia (WA) (61/78 [78.2%]) that were collected during the 2013–2017 epidemic
Summary
Pertussis remains a major public health concern. In many industrialized countries, including Australia, whole-cell vaccine was replaced by the less reactogenic acellular vaccine (ACV). The Study We sequenced 78 B. pertussis isolates (Appendix 1 Table 1) from New South Wales (NSW) (17/78 [21.8%]) and Western Australia (WA) (61/78 [78.2%]) that were collected during the 2013–2017 epidemic. The 3 noncluster I SP18 isolates had a fim3A* allele that differs from fim3A by a synonymous mutation [3] with genotype ptxP1-fim3A*-prn1. One isolate (L2263 [SP18]) contained a fim2 allele with a new 3-nucleotide insertion (AGA) at position 506, resulting in the insertion of a lysine in the epitope (F2.9) region of Fim2 [5].
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