Abstract
ABSTRACT In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.
Highlights
The findings present in the Iqbal et al manu script [14] on the H2S signaling of autophagy in an animal system, together with previous findings acquired in plant stu dies, highlight persulfidation as a molecular mechanism under lying autophagy regulation, being a conserved mechanism in both eukaryotes
We highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/ divergencies with plant cells
In the recent study published by Iqbal et al. [14], persulfi dation was demonstrated as the underlying mechanism of the regulation of autophagy by H2S in mammalian cells, as like wise was previously highlighted in the plant Arabidopsis thali ana [13]
Summary
The findings present in the Iqbal et al manu script [14] on the H2S signaling of autophagy in an animal system, together with previous findings acquired in plant stu dies, highlight persulfidation as a molecular mechanism under lying autophagy regulation, being a conserved mechanism in both eukaryotes. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism. KEYWORDS Arabidopsis; GAPDH; hydrogen sulfide; persulfidated cysteine; posttranslational modification; stress
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