Abstract
Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of Ocimum basilicum and Trifolium pratense in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (Trifolium sp. and Ocimum sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts.
Highlights
Plants have been sources of minerals, vitamins and bioactive compounds since ancient times that are used in traditional medicine to treat various diseases
Ocimum species is characterized by an abundance of compounds such as phenolic acids, and volatile oils, and Trifolium species have been shown to be rich in biologically active compounds such as isoflavones [6,7]
Studies on the antimicrobial properties of Trifolium pratense included a comparison of the actions of different extracts, all pathogens examined were inhibited by the extract made in methanol, which was declared to have the highest antibacterial and antifungal activity [46,69]
Summary
Plants have been sources of minerals, vitamins and bioactive compounds since ancient times that are used in traditional medicine to treat various diseases. Basil has been utilized traditionally for curing health issues such as: anxiousness, stings, strong aching, gripe, pyrexia, infective diseases, headaches, coughs, constipation, warts, worms and kidney malfunction [12,13,14] It was used as a deodorant, being considered to be an aphrodisiac [15]. This review considers the combination of the two species, based on the common bioactive compounds identified in their composition, along with their similar therapeutic activities. One of these similar biological activities is the healing of wounds. Some preliminary results confirm the high therapeutic potential combining the extracts from both plants, working synergistically with great benefits
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