Perspectives of using of somatic cells fusion process in some aspects of car¬cino¬ge-nesis

Abstract

Normal somatic cells sensitive to carcinogenic effects and capable of proliferation form firstly a binuclear cells (dikaryons) and then hybrid cells (mononucleated synkaryons) by means of fusion with another cells of the same organism, in particular with differentiated and non-differentiated cells of corresponding tissue or with cells capable to migrate. In all probability, during the perforation of the plasma membrane, i.e., after the formation of po­res, induced by different carcinogenic (and noncarcinogenic) agents and factors, the total negative charge of plasma membrane changes (decreases) and the cells develop the ability to come closer to each other, whi­ch will probably be the prerequisite to a fusion process. On the other hand, it is not excluded that perforation can assist the fusion of only neighboring cells. Initially, a set of chromosomes in a precancerous cell retains, even for a short time, the condition of tetraploidy. Because of cell fusion generates tetraploidy, it potentially might cause chromo­somal instability. The article emphasizes a possibility of using the fusion process in different aspects of carcino­genesis (therapy, prevention, etc.).