Perspectives of gold nanoparticles and their applications in pancreatic cancer (Review)

Abstract

Nanoparticles (NPs) represent a major point of interest in the scientific field, with an increasing number of studies revealing promising results. Nano-oncology is a relatively new area of research that continues to expand, revealing new perspectives in both diagnosing and treating cancer. Treating pancreatic cancer (PC) remains a major challenge, with modest positive results, thus an increasing number of studies have focused on this disease. Out of all the NPs that have been used in experimental studies, gold NPs (GNPs) appear to be the most efficient, with little systemic toxicity. This review aims to summarize the latest studies that reveal the effects that GNPs have on PC cells, focusing on different ways in which they can be used to diagnose this disease, to induce apoptosis or cause cytotoxicity in cancer cells. Although literature has limited data concerning this specific topic, the results are promising. However more studies are required until GNPs can be used in clinical practice.