Abstract
Background. Human health is largely determined by the body’s resistance to various damaging factors and, in particular, the functional state of its immune system. The use of unique, new generation immunomodulators in prevention of diseases is promising. Goal of the research was to defne the perspectives in the application of immunocorrector Transfer factorTM in immunoprophylaxis programmes and immunorehabilitation analysing and summarizing scientifc articles. Methods. Systemic literature overview was performed, including 77 scientifc articles and conference proceedings in English, published in the period from 1949 to 2016. The main inclusion criterion was clinical trial or literature review, analysing the effect of immunocorrector on human health in cases of different disorders. Results. Transfer factors are molecules that communicate antigenic immunological information intracellularly from a donor to a recipient. Mammalian Transfer factors, including those of humans are small molecules between 3,500 and 10,000 Daltons. Transfer factor’s functions of cell-mediated immunity and non-specifc immunological activity differ from the functions of antibodies. Transfer factors are divided into three fractions: the inductors that provide rapid immune response and general readiness of the immune system; suppressors, which regulate the intensity of the immune response, preventing allergic and autoimmune reactions; antigen specifc Transfer factors with a set of certain antigens, allowing quick adjusting of the immune system to recognize many bacterial and viruses. Conclusions. Transfer factors have no side effects and are considered as highly effective in treatment of infectious, parasitic, oncological, dermatological, venereal and somatic diseases, so are highly recommended for preventive purposes and decreasing of aging.]Keywords: transfer factor, immunoprophylaxis, immunorehabilitation.
Highlights
According to the modern concepts, 80% of human diseases are directly or indirectly associated with adverse environmental conditions
Transfer factor’s functions of cell-mediated immunity and non-specific immunological activity differ from the functions of antibodies
Transfer factors are divided into three fractions: the inductors that provide rapid immune response and general readiness of the immune system; suppressors, which regulate the intensity of the immune response, preventing allergic and autoimmune reactions; antigen specific Transfer factors with a set of certain antigens, allowing quick adjusting of the immune system to recognize many bacterial and viruses
Summary
According to the modern concepts, 80% of human diseases are directly or indirectly associated with adverse environmental conditions. It has been generally recognized that human health is largely determined by the body’s resistance to various damaging factors and, in particular, the functional state of its immune system. Constant exposure of anthropogenic environmental pollutants on human body depletes the capacity of the immune system, the body’s adaptive reserves and the emergence of a wide range of diseases of civilization. This is a partial explanation for increased frequency of cancer and other diseases, which are characterized by common disorders in the body and a significant suppression of the immune system (Agadzhanian, Chizhov, 2003). Goal of the research was to define the perspectives in the application of immunocorrector Transfer factorTM in immunoprophylaxis programmes and immunorehabilitation analysing and summarizing scientific articles
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