Abstract
A major contribution of physicists in nuclear medicine, jointly with mathematicians, was to invent and develop dedicated tomographic reconstruction methods. However, the ultimate dream of each physicist is to develop acquisition systems recording sufficient information for each detected event to allow the direct determination of the decay location that generated this event. Two different ways are possible to achieve this ultimate goal: (1) in TOF-PET, by an accurate measure of the delay separating the detection of the two coincident collinear 511 keV γ-rays, and (2) in SPECT, by the measure of the incoming direction of two coincident noncollinear γ-rays. Obviously, this last method requires isotopes owning a γ-ray cascade in their decay scheme.
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