Abstract
Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and recommendations for addressing compelling scientific questions for late stage (T4) research-research that studies implementation strategies for proven effective interventions-to inform and guide the National Heart, Lung, and Blood Institute's global health research and training efforts. Major themes emerged in two broad categories: 1) developing research capacity; and2) efficiently defining compelling scientific questions within the local context. Compelling scientific questions included how to deliver inexpensive, scalable, and sustainable interventions using alternative health delivery models that leverage existing human capital, technologies and therapeutics, and entrepreneurial strategies. These broad themes provide perspectives that inform an overarching strategy needed to reduce the heart, lung, blood, and sleep disorders disease burden and global health disparities.
Highlights
Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middleincome countries
Major themes emerged in two broad categories: 1) developing research capacity; and 2) efficiently defining compelling scientific questions within the local context
During this same time frame, major noncommunicable diseases (NCD) had substantial reductions in their age-specific mortality rates, these reductions have been uneven across high, middle, and low-income countries [5]
Summary
Past and current NIH and NHLBI leadership support engagement in global health research. Research teams, partners, and stakeholders in the NHLBI research community will be needed. Tailoring efforts to low- and middle-income countries considers the “6 Cs”: customizing appropriately for country-income level, context-specific to the local environment, capacity building foci, countrydriven priorities, and targeting critical challenges, and compelling questions for high-priority HLBS health issues [46]. The in-country research cadre can build regional and global collaborations with both peer countries and with high-income country institutions. This effort aligns with the NIH and NHLBI’s commitment to develop and foster a robust T4 biomedical research workforce capable of tacking today’s challenges
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