Abstract
Background According to EU legislation, genetically modified plants (GM plants) should follow a scientific assessment of any risk that they may pose to human and animal health, including an allergenicity assessment. According to the EFSA guidance, the allergenicity assessment of GM plants is structured into the assessment of i) the newly expressed proteins and ii) the whole GM plant. For the latter and as a part of the assessment, if the GM plant receiving the introduced gene(s) is known to be allergenic, its endogenous allergenicity is compared with that of its non-GM comparator(s).
Highlights
According to EU legislation, genetically modified plants (GM plants) should follow a scientific assessment of any risk that they may pose to human and animal health, including an allergenicity assessment
New analytical methods and profiling techniques not based on human sera are evolved and could be used for these purposes. In view of these new developments, EFSA recommended the possible inclusion of key allergens in the comparative compositional analysis to limit the use of human sera [1,2]
There are several limitations associated with the use of human sera, e.g. availability, reproducibility, variability from allergic individuals, difficulty of obtaining wellcharacterised allergic individuals and sera, etc
Summary
According to EU legislation, genetically modified plants (GM plants) should follow a scientific assessment of any risk that they may pose to human and animal health, including an allergenicity assessment. According to the EFSA guidance, the allergenicity assessment of GM plants is structured into the assessment of i) the newly expressed proteins and ii) the whole GM plant. For the latter and as a part of the assessment, if the GM plant receiving the introduced gene(s) is known to be allergenic, its endogenous allergenicity is compared with that of its non-GM comparator(s)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
