Abstract
Cell membranes are dynamic and complex structures, and their composition and structure are major determinants of pathology. It is now commonly accepted that the membranes' physical properties, such as fluidity and thickness, are determining factors for permeability, partitioning of drug molecules, and protein aggregation. Membrane-interacting molecules can in some instances be expected to have a greater therapeutic potential than traditional therapies targeting receptors or enzymes. Alzheimer's disease is an example where traditional approaches thus far have been proven unsuccessful. With bacteria becoming resistant to more and more antibiotics, potential membrane based antibiotics provide an alternative route with great potential. Here, we provide a perspective on the basic mechanisms how physical membrane properties can affect diseases and the therapeutic potential of changing membrane lipid composition and properties to target those diseases. Neurodegenerative diseases, such as Alzheimer's disease, and infectious diseases, are prime examples among many others where the so-called Membrane-Lipid Therapy shows great potential for the development of new drugs and new therapies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.