Abstract
This special issue of Neuropsychiatric Genetics presents both a comprehensive overview of and the latest progress in the genetics of Attention Deficit/Hyperactivity Disorder (ADHD). In many ways, this issue’s wide range of topics reflects how genetics and our understanding of ADHD have developed over the course of the last 25 years. This issue includes the phenotypic interrogation of ADHD in families to assess heritability and the suitability of measures; linkage analysis of clinical and quantitative phenotypes; candidate gene association studies of biologically relevant hypotheses; genetic analyses of endophenotypes and comorbid disorders; gene expression in an animal model of ADHD; and, finally, a sequence of articles describing the genome-wide association scan (GWAS) from the International Multi-site ADHD Gene (IMAGE) Project. This set of articles recapitulates the major trends in the field of complex psychiatric genetics, underscoring how genetic studies of ADHD have evolved, and what approaches are needed to uncover the genetic etiology. Among the common psychiatric diseases, ADHD is one of the
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