Persons with multiple sclerosis older than 55years: an analysis from the German MS registry.

Abstract

Persons with MS (PwMS) ≥ 55years are underrepresented in therapy studies leading to a lack of evidence. To study the subgroup of PwMS ≥ 55years in the German MS registry in comparison with PwMS < 55years. Endpoints of interest were the grade of disability, leading symptoms, clinical and magnetic resonance imaging activity, and use of disease modifying therapy. At the time of analysis, data from 40,428 PwMS were available for analysis. In PwMS aged ≥ 65 and PwMS aged ≥ 55 to 64years, compared with PwMS aged < 55years, the mean Expanded Disability Status Scale Scores were higher (5.3, 4.2 and 2.7, respectively), while the proportion of individuals with current use of disease modifying therapy was lower (42.6%, 60.9% and 76.7%, respectively). The older patient groups were more likely to be labeled with progressive MS and the frequency of occupational invalidity was high (38.8% in PwMS aged ≥ 55 to 64years). Gait disorder, fatigue, bladder dysfunction, and spasticity were among the leading symptoms in PwMS aged ≥ 55years. PwMS ≥ 55years have a high degree of disability, but a large proportion do not receive disease modifying therapy, exposing an unmet need.