Personalized Variable vs Fixed-Dose Systemic Corticosteroid Therapy in Hospitalized Patients With Acute Exacerbations of COPD: A Prospective, Multicenter, Randomized, Open-Label Clinical Trial

Abstract

Systemic corticosteroids for the treatment of COPD exacerbations decrease treatment failure and shorten the length of hospitalization. However, the optimal dose is unclear. Is personalized-dose corticosteroid administered according to a dosing scale more effective than fixed-dose corticosteroid administration in hospitalized patients with COPD with exacerbations? This was a prospective, randomized, open-label trial. In-hospital patients with COPD with exacerbations were randomly assigned at a 1:1 ratio to either the fixed-dose group (receiving the equivalent of 40mg of prednisolone) or the personalized-dose group for 5days. The primary end point was a composite measure of treatment failure that included in-hospital treatment failure and medium-term (postdischarge) failure. Secondary end points were length of stay and cost. A total of 248 patients were randomly assigned to the fixed-dose group (n= 124) or personalized-dose group (n= 124). One patient in each group was not included in the intention-to-treat population because of incorrect initial COPD diagnosis. Failure of therapy occurred in 27.6%in the personalized-dose group, compared with 48.8%in the fixed-dose group (relative risk, 0.40; 95%CI, 0.24-0.68; P= .001). The in-hospital failure of therapy was significantly lower in the personalized-dose group (10.6%vs24.4%; P= .005), whereas the medium-term failure rate, adverse event rate, hospital length of stay, and costs were similar between the two groups. After treatment failure, a lower additional dose of corticosteroids and a shorter duration of treatment were needed in the personalized-dose group to achieve control of the exacerbation. In the personalized-dose cohort, those receiving 40mg or less had an average failure rate of 44.4%, compared with 22.9%among those receiving more than 40mg (P= .027). Personalized dosing of corticosteroids reduces the risk of failure because more patients were provided with a higher initial dose, especially > 60mg, whereas 40mg or less was too low in either group. ClinicalTrials.gov; No.: NCT02147015; URL: www.clinicaltrials.gov.