Abstract
Physical health status may be predictive of readmissions, psychological health and mortality in patients with short bowel syndrome. This study aimed to investigate the feasibility and effect of an individualized exercise intervention and secondary, oral nutrition intake counseling on Timed-Up-and-Go (TUG) and 30s Chair Stand Test (CST) as well as body-composition and EuroQol (EQ)-5D-5L, in patients with chronic intestinal failure (IF) type III receiving HPN and/or fluid therapy. A 12-week individualized exercise intervention consisting on three weekly home based sessions, and nutrition counselling focusing on protein intake and reducing high stoma output, was performed. Weekly follow-up by phone was done on motivation to exercise. The study invited 71 patients, 44 accepted the invitation (62%), 37(52%) were included, and 31 (84%) completed the intervention. The exercise intervention was well tolerated. TUG improved from 8.9(SD 5.5) to 7.7(SD 3.8) (p=0.033). CST improved by four repetitions (<0.001∗). A statistical, however not clinically relevant improvement was seen in muscle mass. No improvement was seen in (EQ)-5D-5L total, but insignificantly (p=0.055) for physical function only. Protein intake improved by 10.6g/day (p=0.008). A 12 weeks individualized exercise intervention showed very feasible and beneficial in HPN patients. Physical function improved statistically and clinically, and oral protein intake improved. QoL overall did not improve, however COVID-19 was an uninvited partner throughout the study period, which may have influenced general QoL. As only 62% accepted the invitation to participate, home based exercise intervention may not apply to all patients.
Highlights
Physical health status may be predictive of readmissions, psychological health and mortality in patients with short bowel syndrome
The aim of this study was to investigate the feasibility and effect of an individual home based, three times weekly exercise intervention and counseling regarding oral nutrition intake on Physical Function (PF) measured by Timed-Up-and-Go (TUG) and 30 s Chair Stand Test (CST) as well as body-composition and Quality of life (QoL) measured by EuroQol (EQ)-5D-5L, in patients with chronic intestinal failure (IF) type III receiving HPN and/ or fluid therapy
This study aimed to investigate the feasibility and effect of combined individual exercise primarily focusing on strength training and oral nutrition intake counseling on PF, and secondarily body composition and QoL in patients with chronic IF type III receiving HPN and/or fluid therapy
Summary
Physical health status may be predictive of readmissions, psychological health and mortality in patients with short bowel syndrome. Short Bowel Syndrome (SBS), known as IF type III, is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation (IVS) is required to maintain health and/or growth” [1]. It is caused by various underlying pathophysiological gastrointestinal or systemic diseases such as Crohn's Disease, radiation damage, as a cause of vascular complications, large bowel resections or trauma [2e4]. No studies are found regarding daily activity levels in HPN-patients
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