Abstract

Objective To evaluate the clinical significance of personalized biomechanical modeling of prostate deformation based on ultrasound elastography for magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) image registration. Methods A total number of 5 patients and 1 commercial prostate phantom were imaged via transrectal ultrasound elastography, 3D-TRUS and MRI from June 2016 to December 2016. A personalized biomechanical model via the patient-specific ultrasound elastography was made for the deformable registration of prostate MRI and 3D-TRUS images. The registration accuracy was evaluated by the target registration error (TRE) and also the t-test was conducted to validate the statistical significance of our results. Results All the 5 sets of patient data as well as the phantom data were successfully registered. The TRE value of the phantom data was 1.65 mm. The mean TRE value of 5 patients was 1.31 mm, compared with the 2.52 mm TRE value of the registration method without patient-specific biomechanical properties via elastography, was approximately 48% lower(P<0.05). Conclusions Personalized biomechanical modeling of prostate deformation based on ultrasound elastography for MRI-TRUS image registration possesses important clinical significance and is a promising way to provide more quality guidance and improve the accuracy of prostate biopsy. Key words: Elasticity imaging techniques; Three-dimensional transrectal ultrasound; Medical image registration; Biomechanical model

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