Abstract
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных и вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии лекарственных средств на плод, о проводимых в
Highlights
Efficacy of interferon therapy for chronic hepatitis (Hepatitis C Virus, HCV) in children varies from 0.0 to 90.0% depending on the applied treatment regimens and HCV genotype [1-14]
We conducted virological response monitoring in accordance with recommendations of the European Association for the Study of the Liver (EASL) [16] in order to assess efficacy of antiviral therapy: determination of quantitative expression of HCV genes (RNA) in blood serum with polymerase chain reaction (PCR) before the treatment and 4, 12, 24, 48 and 72 weeks after the therapy initiation. ● Fast virological response (FVR) was registered if HCV RNA was not detected (≤ 50 IU/ml) after 4 weeks of treatment. ● Early virological response (EVR) was registered if HCV RNA was not detected after 12 weeks of therapy, but was positive after 4 weeks
In order to determine treatment response predictors, we considered the children with primary virological remission (PVR) “responding”, the children without PVR in the setting of the conducted interferon therapy – “non-responding”
Summary
Efficacy of interferon therapy for chronic hepatitis (Hepatitis C Virus, HCV) in children varies from 0.0 to 90.0% depending on the applied treatment regimens and HCV genotype [1-14]. Fast virological response and early virological response are predictors of favorable interferon therapy outcome in adults – sustained virological remission (SVR) is achieved in 89 and 70% of cases, respectively [15]. Predictors of positive virological response to interferon therapy in children (necessary to determine the need in and the period of interferon therapy in order to forecast efficacy thereof) have not been determined yet, which is why it is necessary to reveal them and develop individualized treatment regimens producing the best possible effect on their basis. Objective: develop personalized chronic hepatitis C treatment regimens for children on the basis of the revealed virological response predictors and retrospective assessment of efficacy of the conducted interferon therapy
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