Abstract
No study has evaluated the impact of different iodinated contrast media on coronary contrast enhancement, using an injection protocol according to body surface area (BSA). Thus, the present study aimed to examine the usefulness and safety of personalized application of different iodine concentrations of contrast media in coronary computed tomographic (CT) angiography with a 2nd dual‐source CT scanner in eliminating differences in coronary contrast enhancement based on a BSA‐adapted injection protocol of contrast media. A total of 270 enrolled participants were randomly assigned to three groups: ioversol 320, ioversol 350 and iopromide 370 (n = 90 per group). The three groups were administered contrast media at a BSA‐adjusted volume and flow rate with a fixed injection time of 15 seconds, and they subsequently received a 30‐mL saline flush. All patients were scanned with a prospective electrocardiogram‐gated protocol in a craniocaudal direction using a second‐generation 128‐slice dual‐source CT system. The three iodinated contrast media used in coronary CT angiography exhibited similar diagnostic quality and safety. No significant differences were found in the contrast enhancement degrees, image quality scores, radiation doses and incidences of adverse effects among the three groups. The three contrast media used in coronary CT angiography with 320, 350 and 370 mg/mL iodine, respectively, have comparable diagnostic quality and safety. However, more large‐scale, multinational, multi‐centre and prospective trials are warranted.
Highlights
Non-invasive computed tomography (CT) angiography, especially coronary CT angiography, has attracted increasing attention and has been widely used in the diagnosis of cardiovascular diseases
Iodine load was calculated as the concentration multiplied by total volume of contrast media, and iodine delivery rate was calculated as the concentration multiplied by injection rate of contrast media
No significant differences in sex, age, bodyweight, height, body mass index (BMI), body surface area (BSA), heart rate and blood pressure were noted among the 3 groups (Table 2)
Summary
Non-invasive computed tomography (CT) angiography, especially coronary CT angiography, has attracted increasing attention and has been widely used in the diagnosis of cardiovascular diseases. These CT devices include a 64-row spiral CT scanner, post-64-row CT scanner and dual-source CT scanner.[1]. No study has reported the effects of different iodinated contrast media on coronary contrast enhancement, using a standardized injection protocol based on BSA or bodyweight. The present study aimed to evaluate the usefulness and safety of the personalized application of different iodine concentrations of contrast media in coronary CT angiography with the second-generation dual-source CT scanner in eliminating differences in coronary contrast enhancement based on the BSA-adapted injection protocol
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