Abstract
Aim of this study was to analyze personality traits in patients with neuroepithelial brain tumors. Personality alteration is a common feature in brain tumor patients, but not much is known about associations between specific personality changes and brain tumors. We assessed potential factors influencing personality such as tumor location, tumor grade and tumor volume. Mini-mental state examination (MMSE), Beck’s Depression Inventory II (BDI-II), and the NEO Five-Factor Inventory (NEO-FFI) for the five factors of personality were acquired. Patients had lower scores regarding the factor openness and higher scores regarding the BDI-II compared to the norm population. No significant influencing factors (tumor entity, location) were found regarding personality traits. Neuroticism was associated with depression, whereas extraversion showed an opposed association. Patients with intrinsic brain tumors have differences in personality traits compared to the control population, with an emphasis on the factor openness. No significant confounding factors like tumor grade, entity, or location were found for personality traits.
Highlights
In modern medicine, personality changes due to brain damage have been known for a long time
Since there are no prospective studies focusing on personality traits and the correlation between personality traits and depression in patients with intrinsic brain tumors, the aim of this study was to outline factors that influence the personalities of patients with neuroepithelial tumors
This study investigated personality traits and depression in patients with intrinsic brain tumors
Summary
Personality changes due to brain damage have been known for a long time. One of the first modern reports of personality changes is the one of Phineas Gage, a railroad construction foreman who survived a penetrating wound and damage to the prefrontal cortex by an iron rod. Alzheimer’s disease was shown to be associated with high neuroticism and low openness/extraversion and conscientiousness; these personality traits are discussed as risk factors for dementia[13,14,15]. Oligodendroglioma WHO grade IV - glioblastoma - medulloblastoma Preoperative tumor volume - T2 FLAIR (cm3) - T1 contrast (cm3) Postoperative tumor volume - T2 FLAIR (cm3) - T1 contrast (cm3) Main tumor location - frontal - parietal - temporal - infratentorial - midline - multilobular without midline - multilobular with midline - ventricle Location, hemisphere - right - left - midline - both Personality traits - neuroticism - extraversion - openness - agreeableness - conscientiousness Depression - BDI-II Oligoastrocytoma - anapl. oligodendroglioma WHO grade IV - glioblastoma - medulloblastoma Preoperative tumor volume - T2 FLAIR (cm3) - T1 contrast (cm3) Postoperative tumor volume - T2 FLAIR (cm3) - T1 contrast (cm3) Main tumor location - frontal - parietal - temporal - infratentorial - midline - multilobular without midline - multilobular with midline - ventricle Location, hemisphere - right - left - midline - both Personality traits - neuroticism - extraversion - openness - agreeableness - conscientiousness Depression - BDI-II
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