Abstract
Inter individual genetic variation contributes to both disease susceptibility and response to drugs. The genetic makeup of every individual isdistinctive, henceforth there are variations in the gene products. It is also responsible for the phenotypic diversity, which results in the differentcapacity of each individual to respond to exogenous substances, such as drugs and xenobiotics, and in the different propensity to induceundesirable health effects. So, the aim of personalised medicine is to increase the possibility of therapeutic efficiency and to decrease the drugtoxicity risk for an individual patient.Int J Appl Sci Biotechnol, Vol 3(2): 139-142 DOI: http://dx.doi.org/10.3126/ijasbt.v3i2.12545
Highlights
Variation in Gene Sequence Gene-environment interactions refer to effects in which human genetic variability governs differential responses to environmental exposures
The paraoxonase 1 gene (PON1) encodes an enzyme involved in the metabolism of chlorpyrifos, an organophosphate pesticide, widely used in agricultural settings to protect crops from insects
It has been shown (Jaenisch R and Bird A, 2003) that, epigenetic regulation of cell phenotypes is DNA methylation, which turns off a gene or gene region by changing the chemical structure of the DNA
Summary
CrossRef, Google Scholar, Global Impact Factor, Genamics, Index Copernicus, Directory of Open Access Journals, WorldCat, Electronic Journals Library (EZB), Universitätsbibliothek Leipzig, Hamburg University, UTS (University of Technology, Sydney): Library, International Society of Universal Research in Sciences (EyeSource), Journal Seeker, WZB, Socolar, BioRes, Indian Science, Jadoun Science, JourInformatics, Journal Directory, JournalTOCs, Academic Journals Database, Journal Quality Evaluation Report, PDOAJ, Science Central, Journal Impact Factor, NewJour, Open Science Directory, Directory of Research Journals Indexing, Open Access Library, International Impact Factor Services, SciSeek, Cabell’s Directories, Scientific Indexing Services, CiteFactor, UniSA Library, InfoBase Index, Infomine, Getinfo, Open Academic Journals Index, HINARI, etc. Impact factor*: 1.422 Scientific Journal Impact factor#: 3.419 Index Copernicus Value: 6.02
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