Abstract
The emergence of pathogens resistant to antimicrobials has prompted political initiatives targeting a reduction in the use of veterinary antimicrobials in Denmark, especially for pigs. This study elucidates the tendency of pig farms with a significantly higher antimicrobial use to remain in clusters in certain geographical regions of Denmark. Animal Daily Doses/100 pigs/day were calculated for all three age groups of pigs (weaners, finishers and sows) for each quarter during 2012–13 in 6,143 commercial indoor pig producing farms. The data were split into four time periods of six months. Repeated spatial cluster analyses were performed to identify persistent clusters, i.e. areas included in a significant cluster throughout all four time periods. Antimicrobials prescribed for weaners did not result in any persistent clusters. In contrast, antimicrobial use in finishers clustered persistently in two areas (157 farms), while those issued for sows clustered in one area (51 farms). A multivariate analysis including data on antimicrobial use for weaners, finishers and sows as three separate outcomes resulted in three persistent clusters (551 farms). Compared to farms outside the clusters during this period, weaners, finishers and sows on farms within these clusters had 19%, 104% and 4% higher use of antimicrobials, respectively. Production type, farm type and farm size seemed to have some bearing on the clustering effect. Adding these factors as categorical covariates one at a time in the multivariate analysis reduced the persistent clusters by 24.3%, 30.5% and 34.1%, respectively.
Highlights
In Denmark, 29 million pigs are produced annually accounting for 76% of prescribed veterinary antimicrobials [1]
Data from the Specific Pathogen Free (SPF) system were extracted in March 2013, while data on farm demographics were retrieved from the Central Husbandry Register (CHR) in January 2012 and October 2013
Based on data from the CHR and from the SPF register, farms included in the analyses are described by their SPF status, production type, and farm size (Table 1)
Summary
In Denmark, 29 million pigs are produced annually accounting for 76% of prescribed veterinary antimicrobials [1]. A number of legislative actions targeting a reduction in the use of antimicrobials for pigs have been launched in Denmark [5,6,7,8]. Antimicrobial treatment of production animals is, according to Danish legislation, restricted to clinical disease, excluding use for prophylaxis and growth promotion [9]. In Denmark, the three age groups of pigs, for which antimicrobials are prescribed are: weaners, finishers and sows (including boars and piglets). The primary clinical reasons for prescribing antimicrobials are gastrointestinal and respiratory disorders for weaners and finishers, and limbs/joints/CNS/skin and urogenital disorders for sows [10]. The choice of drug, dose and treatment time as well as the perception of metaphylaxis all influences the administration of antimicrobials at the farm
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