Persistent Pulmonary Hypertension of the Newborn and Possible Premature Ductal Closure with History of In Utero Exposure to a Selective Serotonin Reuptake Inhibitor

Abstract

Persistent pulmonary hypertension of the newborn more often affects term and near-term infants. It occurs when the anticipated postnatal decrease in pulmonary vascular resistance fails to occur. There is evidence in animal models of premature ductal closure and persistent pulmonary hypertension of the newborn in fetal mice with in-utero exposure to selective serotonin reuptake inhibitors, commonly prescribed antidepressants in pregnancy. This case raises suspicion about an association in a neonate between in-utero exposure to selective serotonin reuptake inhibitors and persistent pulmonary hypertension of the newborn secondary to premature ductal closure.