Persistent papilloma and polyoma virus infection in common variable immunodeficiency with progressive multifocal leukoencephalopathy

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous syndrome in which the main characteristic is hypogammaglobulinemia and impaired specific antibody responses with both B- and T-lymphocyte involvement.1 Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating disease of the central nervous system caused by John Cunningham (JC) virus, a member of polyoma group DNA virus.2 Any level of the central neuraxis may be affected, but the cerebral hemispheric white matter is the most common site, followed by cerebellar and bulbar localization.