Persistent infection of Helicobacter pylori affects weight loss in obese population compared with persistent negative: A case-control study based on healthy Chinese.

Abstract

The relationship between Helicobacter pylori (Hpylori) and body mass index (BMI) is still inconclusive. Not only the high rate of Hpylori infection but also the increasing higher BMI levels are endangering Chinese today. The aim of this research was to evaluate the association between different situations of Hpylori infection and BMI values or levels in Chinese healthy population. A total of 39091 individuals aged from 18years to 80years, performed healthy examination including a 13 C/14 C urease breath test (13 C/14 C-UBT), were included. Among them, 30224 individuals only had one time of health examination, and 8867 had two or more times. A case-cohort data of 8752 with an interval time more than 6months, collected by the first and the last time, were established from the latter. BMI groups are classified according to the China recommendation: low weight (<18.5kg/m2 ), normal weight (18.5~23.9kg/m2 ), overweight (24.0~27.9kg/m2 ), and obesity (≥28.0kg/m2 ). The rate of Hpylori infection among low weight, normal weight, overweight, and obesity was 43.2%, 44.7%, 46.4%, and 48.0%, respectively (P=.000). Hpylori infection increased the risk of higher level of BMI (OR=1.077, 95% confidence interval=1.036-1.119, χ2 =14.048, P=.000) with adjustments for sex and age. In the case-control study, the rate of persistent negative, persistent infection, new infection, and eradicated infection was 39.5%, 25.8%, 15.8%, and 18.9%, respectively, with a median interval time of 13months. The mean obesity BMI descend values in the persistent negative subgroup were lower than those in the persistent infection subgroup (-0.21±1.19kg/m2 vs -0.003±1.01kg/m2 , P=.021). But the change of BMI classifications had no difference between the subgroups of Hpylori infection in different BMI levels. Hpylori infection was positively correlated with higher BMI levels. And Hpylori persistent infection had a negative effect on the fall of BMI values in Chinese obese population.