Abstract
Persistent Emergence of Dengue
Highlights
The disease dengue fever (DF; known as breakbone fever, dandy fever, and by other names) can be caused by any of 4 viruses within the virus family Flaviviridae, genus Flavivirus, i.e., dengue virus types 1–4 (DENV-1–4)
Through a mechanism known as immune enhancement, sequential infections with certain dengue viruses set the stage for a far more serious complication, dengue hemorrhagic fever (DHF) and dengue shock syndrome, so that having uncomplicated DF can presage having DHF [1]
DHF is characterized by high fever, vascular permeability, bleeding, enlargement of the liver, and circulatory failure
Summary
The disease dengue fever (DF; known as breakbone fever, dandy fever, and by other names) can be caused by any of 4 viruses within the virus family Flaviviridae, genus Flavivirus, i.e., dengue virus types 1–4 (DENV-1–4). Through a mechanism known as immune enhancement, sequential infections with certain dengue viruses set the stage for a far more serious complication, dengue hemorrhagic fever (DHF) and dengue shock syndrome, so that having uncomplicated DF can presage having DHF [1]. DHF is characterized by high fever, vascular permeability, bleeding, enlargement of the liver, and circulatory failure (dengue shock syndrome).
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