Abstract
Chromosomes of a number of men exposed to whole-body mixed gamma and fission neutron irradiation, as well as those of five unirradiated control individuals, were examined. Cytological preparations were made from short-term cultures of peripheral blood leukocytes approximately 29 months after the irradiation occurred, The doses were estimated to rarge from 22.8 to 365 rads. Five men received doses estimated to exceed 230 rads; three others received lower doses. In the five control individuals no major chromosomal abnormalities were found, other than the expected low frequencies of chromatid-type aberrations and counts other than 2n = 46. ln cells from the irradiated individuals, however, changes in both chromosome number and fortn were observed. ln the five high-dose cases, the frequency of cells with counts of other than 2n = 46 ranged from 7 to 23%. Grossly altered chromosomes, such as rings, dicentrics, and minutes, were found, often in cells with abnormal counts, with a frequency ranging from 2 to 20 per 100 cells. Two of the three low-dose individuals also show variations in number and form of their chromosomes, but at a much lower frequency than the high- dose cases, (auth)
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