Persistent care should be taken to the research on HBV genomic viability and its clinical translation

Abstract

China is among the middle-high endemic regions of HBV infection. The pathological outcomes of chronic HBV infection have been shown to be greatly influenced by several important factors, including HBV genotype, sub-genotype and gene viability mutation. HBV genome mutation, on the one hand, could alter its replication and secretion and thus change viral pathogenicity. In addition, host immune microenvironment and host-virus interaction, disease progression and the effect of antiviral therapy could be adapted at the same time. The detection of HBV genotypes, genetic subtypes and the key hotspot mutation is helpful to clinical risk assessment and prognosis prediction of HBV-related end-stage liver diseases (cirrhosis and hepatocellular carcinoma), it is also helpful to auxiliary predict the liver diseases recurrence and metastasis after treatment. Thus persistent care should be taken on the HBV mutation and its clinical translation so as to provide solid evidences for the personalized, standardized and fine management of HBV-related liver diseases.（Chin J Lab Med,2014,37:90-92） Key words: Hepatitis B; Hepatitis B virus; Variation (genetics); Carcinoma, hepatocellular; Liver cirrhosis