Abstract
Seizure rates decrease with increasing vagus nerve stimulation (VNS) duration.1 We treated a patient whose improvement during VNS persisted for 16 months after termination of this therapy. A 22-year-old man with static encephalopathy received VNS to treat his medication-resistant mixed seizures. His EEG showed generalized slow spike and waves and multifocal spikes. He had a corpus callosotomy 8 years before and had been treated with carbamazepine, clonazepam, diazepam, ethosuximide, phenytoin, and the ketogenic diet. When VNS was added, his antiepileptic drugs (AEDs) were acetazolamide, gabapentin, phenobarbital, triple bromides, and valproate. His baseline seizure types and rates were generalized convulsive (2/week), atonic (2/week), and atypical absence (5/d). On VNS, his seizure rate gradually decreased such that at 5-year follow-up evaluation, he had no atonic and atypical absence seizures and had only one …
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