Abstract
VARIOUS hypotheses have suggested that environmental stress during development is an aetiological factor in mental illnesses. Such hypotheses have included both biological and psychoanalytical concepts, but they have not explained convincingly any possible mechanism of action of stress. The developing organism has often been shown to be sensitive to various hormonal influences, and steroid and thyroid hormones or stress, given at a critical time during the neonatal period, seem to affect permanently the behaviour and metabolism of growing animals1–3.
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