Abstract
Scrapie of sheep/goats and chronic wasting disease of deer/elk are contagious prion diseases where environmental reservoirs are directly implicated in the transmission of disease. In this study, the effectiveness of...
Highlights
Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative diseases for which there is no effective treatments or cure
Pens were either untreated, power washed, power washed followed by treatment with 20,000 ppm free chlorine for 1 hour or power washed, hypochlorite treated and all surfaces either replaced, re-galvanised or painted
The slower kinetics of the sheep becoming both recto-anal mucosa associated lymphoid tissue (RAMALT) positive, and a longer average time until observation of clinical symptoms in pen D compared to pens B and C are consistent with a lower infectious dose in pen D after the decontamination regime
Summary
Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative diseases for which there is no effective treatments or cure. We demonstrate that on premises that are affected with sheep scrapie, pens cannot be effectively decontaminated either using the recommended decontamination treatments, or using a much more stringent treatment consisting of a complete replacement/re-galvanisation of all metalwork and a complete painting of the pen. Such observations have important implications for the decontamination and restocking of farms following outbreaks of scrapie, and especially in the case of goats, with their lack of scrapie resistant genotypes
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