Abstract
The authors followed up the persistence of measles antibodies at 1-year intervals in children given three different live attenuated measles vaccines. The best results were obtained in a group of children given the attenuated Schwarz strain vaccine; this vaccine, prepared in chick embryo cells, consistently produced sero-conversion rates of 92% over a period of 2–6 years. The lowest sero-conversion rate was observed in children given the Edmonston strain vaccine prepared on dog-kidney cells; here, the vaccine induced a sero-conversion rate of 66% after 5–6 years following the immunization. Proportions of seronegative children in three groups of children, administered the Schwarz strain vaccine, prepared on dog-kidney cells, were shown to vary; nevertheless, no statistically significant differences among these groups could be demonstrated. The average sero-conversion rates in the three groups of children were 97, 91, 85 and 82% following 1, 2, 3 and 4 years after immunization, respectively. The greatest decline in antibody titre was shown to occur between 1 month and 1 year after vaccination. In subsequent years these values may vary.
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