Abstract
Human peripheral blood monocytes cultured in vitro on plastic for up to 28 days supported the proliferation of antigen-specific, HLA-restricted T-cell blasts as well as freshly isolated blood mononuclear cells. Seventy-three percent of adhered monocytes were Ia antigen-positive by immunofluorescence when the cultures were initiated, this proportion fell to 70 ± 13% after 28 days. The antigen-presenting function of cultured monocytes was inhibited by monoclonal anti-Ia antibody as compared with freshly isolated mononuclear cells. These results indicate that human monocytes retain their antigen-presenting function during maturation to macrophages in vitro.
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