Abstract
Administering increasing dosages of 5α-dihydrotestosterone propionate (DHTP) (0, 40, or 80 μ/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 μg/100 g in oil daily) caused significant, equivalent reductions in lordotic responsiveness in rats maintained either on a tryptophan-deficient corn diet or on a corn diet to which L-tryptophan was added. Whole brain concentrations of 5-hydroxytryptamine (5-HT) and of 5-hydroxyindoleacetic acid were approximately two times higher in rats fed corn+tryptophan versus corn alone. These findings suggest that the ability of DHTP to inhibit lordosis probably depends upon some mechanism other than a facilitation of 5-HT release from serotonergic neurons.
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