Abstract
Persistence and biochemical characteristics of cypertnethrin and permethrin in the blood of male rats were studied following oral administration of a single dose containing 10 mg.kg -1 of body weight of each pyrethroid. The highest residue concentrations of cypermethrin (2.38 ug.ml-1) and permethrin (8.83 ug.ml-1) in rat blood tissue were detected 24 h after treatment. After two weeks cypermethrin residues decreased to 0.013 ug.ml -1 , whereas permethrin was not detected. Both pyrcthroids decreased the red blood cell (RBC) count, and packed cell volume (PCV) The greatest reduction in RBC count and PCV occurred at 504 h and 336 h respectively. Moreover, the result of post treatment white blood cell (WBC) count was influenced more by permethrin than by cypermethrin, especially after 80 h, 168 h and 504 h of treatment. However, the blood haemoglobin concentration in treated rats was not affected by either pyrethroid.
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