Abstract
Persimmon (Diospyros kaki) leaves have been used as a traditional or local medicine for multiple diseases in different eastern countries (Japan, Korea, India, and China) for centuries. In the recent past, several studies have used persimmon leaves extract (PLE) against different eye-related diseases. In this review, we discussed the ethnopharmacological use, therapeutic potentials and future opportunities for research using PLE for different ocular disorders based on the latest research. The pieces of information regarding PLE were collected using Pubmed, ACS, Elsevier, EMBASE, Web of Science, CNKI and different books. It can be concluded from this review that PLE probably have therapeutic potential against inflammation and oxidative stress induced disorders like dry eye disease (DED), corneal neurovascularization (CoNV), glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and edema. However, further investigations are required to discover exact biological compounds involved in the pharmacological effects against the aforementioned diseases. Furthermore, clinical trials are needed to be performed before integrating PLE for medicinal use
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