Abstract
Carbon Dots (CDs) responding to Peroxynitrite (ONOO-) and Hypochlorite (ClO-) were synthesised by microwave methodology. To improve the quantum yield, selectivity an sensitivity, CDs were doped with Sulphur, Nitrogen and Phosphorous, Nitrogen (S,N-CDs/P,N-CDs) using urea, cysteine and sodium phosphate.
Highlights
Carbon Dots (CDs) are fluorescent nanoparticles based in carbon with unique optical properties [1,2,3]
Preliminary results shows that the co-doped S,NCDs could be used for the ONOO- detection and the co-doped P,Nitrogen CDs (N-CDs) could be used to the ClO- detection at pH 7.4
They found with the synthesis of co-doped S,N and P,N-CDs with Citric Acid (CA) and UR in the range from 1 to 3 g with 1 g of Cys or SP shows that the more selective and sensitivity ONOO- and ClO- flu
Summary
Carbon Dots (CDs) are fluorescent nanoparticles based in carbon with unique optical properties [1,2,3]. A method based on the fluorescence quenching mechanism of N-CDs was applied in HClO detection showing a relatively fast response time and a linear response range from 0.03 to 15 μM with a LOD of 1 nM. This method has been successfully applied to the determination of HClO in tap and river water with good recoveries showing potential for the detection of HClO in environmental applications [29] Another sensor for HClO based on the fluorescence of CDs was prepared by one-step microwave-assisted procedure. The ONOO- and ClO- quantification capability in standard and in fortified serum solutions with the synthesized were respectively evaluated with the co-doped P,N and S,N-CDs. Citric Acid (CA), Urea (UR), Cysteine (Cys), Hydrogen Peroxide (H2O2), Hydrogen Chloride (HCl), Potassium Superoxide (KO2), Sodium Hypochlorite 3.5% (NaClO), Sodium Nitrite (NaNO2), Sodium Nitrate (NaNO3), Sodium Chloride (NaCl), Sodium Phosphate (Na3PO4, SP), Potassium Chloride (KCl), Ethylenediamine Tetraacetic Acid (EDTA), Iron(II) Sulphate (FeSO4.7H2O), Iron(III) Nitrate [Fe3(NO3)3.9H2O], Magnesium Chloride (MgCl2.6H2O), Copper(II) Sulphate (CuSO4.5H2O), Sodium Phosphate Dibasic (Na2HPO4), Monosodium Phosphate (NaH2PO4), Sodium Hydroxide (NaOH), analytical grade reagents were used. The ROS/RNS addition, in the required concentration to the more adequate CDs dilution, was done in a cuvette with a Hamilton® syringe with permanent agitation while the fluorescence signal is continuously monitored for a period of 10 min
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