Abstract
Candida maltosacan assimilaten-alkane as a sole carbon source and cytochromes P450ALK (P450ALK) are critical for the first oxidation step. Four major P450ALKs that are encoded by genesALK1, ALK2, ALK3andALK5are induced byn-alkane and repressed by glucose at the transcriptional level. In the present work, we found that all these four genes butALK5are transcriptionally activated in response to a peroxisome proliferator, clofibrate. This is the first report on the peroxisome proliferator responsive gene expression in lower eucaryotes.
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