Abstract
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell proliferation, survival, apoptosis, and tumor growth. Activation of PPARs by endogenous or synthetic compounds regulates tumor progression in various tissues. Although each PPAR isotype suppresses or promotes tumor development depending on the specific tissues or ligands, the mechanism is still unclear. In this review, we summarized the regulative mechanism of PPARs on cancer progression.
Highlights
As the nuclear hormone receptor, peroxisomeproliferator-activated receptors (PPARs) consist of PPARα, PPARδ and PPARγ, which are ligand-activated transcription factors
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell proliferation, survival, apoptosis, and tumor growth
Increasing evidences show that PPARα [2, 10,11,12] or PPARγ [7, 8, 13] inhibits tumor progression, which acts as tumor suppressors, while some reports show that PPARα is associated with tumor progression [14,15,16]
Summary
As the nuclear hormone receptor, peroxisomeproliferator-activated receptors (PPARs) consist of PPARα, PPARδ and PPARγ, which are ligand-activated transcription factors. Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell proliferation, survival, apoptosis, and tumor growth. Each PPAR isotype suppresses or promotes tumor development depending on the specific tissues or ligands, the mechanism is still unclear.
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