Abstract
Peroxisome proliferator-activator receptor α (PPARα), a member of the nuclear receptor superfamily, has been implicated in the regulation of inflammation and immune response. Adaptive immune responses are suppressed by exposure to PPARα agonists, resulting in severe thymus and spleen atrophy. In addition, the decline in both T and B cells is due in part to the loss of splenocytes upon exposure to PPARα agonists. Thus, the current study was designed to examine the effect of Wy-14,643, a potent PPARα agonist, on B cell development in bone marrow from wild-type and PPARα-null mice. Significantly decrease in pro/pre-B cell and total B220 + cell was observed in wild-type mice in bone marrow upon Wy-14,643 treatment, but not in PPARα-null mice. Immature and mature B cell populations are not affected. This suggests that PPARα is involved in the development of B cell during lymphoid lineage. However, surprisingly, PPARα mRNA was absent in bone marrow as revealed by RT-PCR. Therefore, the effect of PPARα on B cell development is by an indirect mechanism.
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