Abstract
Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.
Highlights
nanomaterial-mediated phototherapies such as photothermal therapy (NmPTT) relies on photothermal heat and NmPDT mainly relies on reactive oxygen species (ROS)
Limited loading efficiency and release of O2 on oxygen nanocarriers is still a limiting factor [20]. To this end, increased attention has been focused on generating O2 on nanomaterials, on enzyme mimetic nanomaterials, known as “nanozymes”, to overcome tumor hypoxia and mediate cancer therapeutics [21]
We review the advantages of POD mimetic nanomaterials which can catalyze endogenous
Summary
Cancer is one of the leading causes of human mortality [1]. Major problems associated with cancer treatment include the reoccurrence of tumors, tumor metastasis and resistance to chemo drugs [2,3]. Limited loading efficiency and release of O2 on oxygen nanocarriers is still a limiting factor [20] To this end, increased attention has been focused on generating O2 on nanomaterials, on enzyme mimetic nanomaterials, known as “nanozymes”, to overcome tumor hypoxia and mediate cancer therapeutics [21]. 2 ofmi attention has been focused on generating O2 on nanomaterials, on enzyme metic nanomaterials, known as “nanozymes”, to overcome tumor hypoxia and mediate cancer therapeutics [21]. The approach of increasmainly peroxidase (OXD), superoxide dismutase and catalase ing ROS promotes therapeutic efficiency with the use of POD mimetics by mimetic nanomaterials [22]. The approach of increasing ROS promotes therapeutic efovercoming tumor hypoxia in oxygen-dependent.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
