Perovskite nickelates as bio-electronic interfaces

Hai-Tian Zhang,Zhan Zhang,Henry Chan,Gobinda Saha,Subramanian K R S Sankaranarayanan,Shriram Ramanathan,Koushik Ramadoss,Qiuyu Wu,Kaushik Roy,Jong Hyun Choi,Badri Narayanan,Feiran Li,Hua Zhou,Indranil Chakraborty,Alexander A Chubykin,Ganesh Kamath,Fan Zuo

doi:10.1038/s41467-019-09660-6

Abstract

Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering. Here, we report the discovery of spontaneous (no external energy input) hydrogen transfer from biological glucose reactions into SmNiO3, an archetypal perovskite quantum material. The enzymatic oxidation of glucose is monitored down to ~5 × 10−16 M concentration via hydrogen transfer to the nickelate lattice. The hydrogen atoms donate electrons to the Ni d orbital and induce electron localization through strong electron correlations. By enzyme specific modification, spontaneous transfer of hydrogen from the neurotransmitter dopamine can be monitored in physiological media. We then directly interface an acute mouse brain slice onto the nickelate devices and demonstrate measurement of neurotransmitter release upon electrical stimulation of the striatum region. These results open up avenues for use of emergent physics present in quantum materials in trace detection and conveyance of bio-matter, bio-chemical sciences, and brain-machine interfaces.

Highlights

Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering
Functional interfaces between biological and synthetic matter can greatly benefit from hydrogen transfer, which is of broad relevance to bio-sensing and bio-chemical sciences
During the glucose–enzyme–SNO reaction, the hydrogen atoms from the glucose are first transferred to the glucose oxidase (GOx) enzyme as it occurs in nature, and into the SNO lattice

Summary

Introduction

Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering. We present enzyme-mediated spontaneous hydrogen transfer between glucose reaction and SNO devices, as well as interfacing perovskite devices with acute mouse brain slices. During the glucose–enzyme–SNO reaction, the hydrogen atoms from the glucose are first transferred to the GOx enzyme as it occurs in nature, and into the SNO lattice.

Results

Conclusion