Abstract
ABSTRACT Previous studies showed that the activities of certain jejunal glycolytic enzymes (pyruvate kinase (PK), fructose-1-phosphate aldolase (FIPA) and fructose diphosphate aldolase (FDPA)) were reduced in hypogonadal male adults. Adaptive changes in enzyme activities after dietary manipulation were less than in normal males. To learn whether this lack of adaptive changes was related to testosterone deficiency, we performed further studies in 5 hypogonadal males. Jejunal biopsies were performed serially during isocaloric synthetic diets, divided into 7-day treatment periods: carbohydrate (CHO)-free, glucose, fructose, CHO-free, CHO-free plus testosterone, glucose plus testosterone, and fructose plus testosterone. Samples of jejunal mucosa were assayed for glycolytic enzyme activities. The results show adaptive changes of all enzymes following dietary manipulation. A marked increase in dietary adaptation of PK occurred with administration of oral testosterone, 10 mg daily. The results show that oral tes...
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