Permeation of drug through a model membrane consisting of millipore filter with oil.

Abstract

An investigation was done on the permeation of drug through the model membrane consisting of Millipore filter saturated with an oil, indicating that the method employed here might be satisfied for obtaining the permeation curve with an excellent reproducibility. The theoretical treatment of the data obtained by this method proved that the permeation of drug through the present system depended on the diffusion mechanism. The ionized molecules of salicylic acid and aminopyrine did not permeate through the membrane. The temperature dependence of the permeation was well expressed by Stokes-Einstein's equation concerning diffusion constant. The experiment using different oils showed that the permeability constant increased with the increase in distribution constant in oil and decreased with the increase in viscosity of oil. Actually, the apparent permeability constant increased proportionally with the increase in distribution constant in oil, and decreased with the increase in the viscosity of the oils used.