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Abstract
The permeability to various cations of the voltage-dependent sodium channel of isolated rat hippocampal pyramidal neurons was investigated under the voltage-clamp condition. The neurons were dispersed enzymatically and mechanically and perfused internally using a suction pipette technique. The permeability sequence, estimated from the reveral potential of the inward current was Li + > Na + > hydrazine + > formamidine + > guanidine + > methylguanidine + > monomethylamine +. Thus the ionic selectivity of the voltage-dependent sodium channel of rat central nervous system neurons is similar to that in the squid axon, myelinated frog nerve fiber and rat ventricle muscle.
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