Abstract
The endocochlear potential and Cl − activities in the endolymph and perilymph of guinea pigs were simultaneously measured with a pair of double-barreled Cl −-sensitive liquid-membrane electrodes. Under normal conditions the mean Cl − activity was 96.6 mEq/l in the endolymph and 93.5 mEq/l in the perilymph. The mean Cl − concentration determined by potentiometric titration was 132.3 mM in the endolymph and 121.8 mM in the perilymph. The permeability to Cl − of the cochlear partition was determined after active transport was abolished by permanent anoxia. The modified permeability coefficient and conductance for Cl − of the cochlear partition were computed from the rate of decrease in the Cl − concentration of the endolymph and its electrochemical potential difference between the endolymph and perilymph. The mean modified Cl − conductance and permeability coefficient of the cochlear partition were (10.7±4.25)×10 −3 Ω −1·cm −3 and (22.58 ± 8.95)×10 −6 s −1 respectively, when averaged from 10 to 30 min after onset of anoxia. Our results indicate that the cochlear partition is relatively permeable to Cl −, when compared to its permeability to K +. Possible coupling between Cl − and water movement across the cochlear partition is discussed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
