Permeability of Piroxicam with Sodium Lauryl Sulfate as Surfactant

Abstract

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) which have characteristic insoluble in water and poorly fluidity. The profile absorption from piroxicam was depend on its dissolution rate in the gastrointestinal tract (GI). To improve the solubility in the water, it can used Sodium Lauryl Sulfate (SLS) as a surfactant which have mechanism by forming a micelle. The aim of this study was to measure the influence gradiet concentration of SLS with Piroxicam absorption that can observe by inverted intestinal sac method. The concentration of piroxicam solution that added by SLS are 1, 2, and 3% respectively. The preparation method using Crane and Wilson tube containing mucosal fluid. After preparation, it was taken at 37°C in waterbath and added with serosal solution to intestinal sac by turned upside down and tied to a cannula. The sample was placed in the tube containing mucosal fluid and constantly flowing by oxygen gas. To measure the absorsion of piroxicam that used serosal solution which every 15 minutes was taken on tube. After this, it was diluted using Ba(OH)2 and ZnSO4 then continuous with separating process. The absorbant of supernatant was measured using Spectrophotometer UV-Vis. Data analyse was calculated by one-way ANOVA. According to Pm, the values 0.25x10-3 cm/minute (0% SLS), 0.39x10-3 cm/minute (1% SLS), 1.45x10-3 cm/minute (2% SLS) and 1.26x10-3 cm/minute (3% SLS) respectively. In conclusion, 2 % SLS significantly give the highest absorption of piroxicam by altering the membrane permeability.