Abstract
Diffusion rate constants of nonsteroidal anti-inflammatory drugs through an artificial lipid membrane were measured by using a Sartorius absorption simulator, and also lipid-water partition coefficients of these drugs were determined spectrophotometrically. The permeabilities of naproxen, indomethacin, flufenamic acid and aminopyrine except benzydamine hydrochloride through an artificial intestinal membrane were higher than those through an artificial gastric membrane. The permeabilities through an intestinal membrane of these drugs decreased in the order of flufenamic acid> naproxen> indomethacin> aminopyine> benzydamine hydrochloride. These results suggest that a correlation between diffusion rate constant and partition coefficient is not necessarily parallel in drugs which do not have similar chemical structures.
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