Abstract
Abstract The question as to whether latex membranes are pervious to anti-cancer drugs or not is closely associated with the risk during the manipulation of cytostatic drugs with latex gloves. We investigated the permeability of thick latex gloves (Sempermed Protector™) to 12 widely used anti-cancer drugs in dialysis experiments and analysed the dialysate by high-performance liquid chromatography or by capillary gas chromatography. Methotrexate, arabinofuranosylcytosine (Ara-C), 5-fluorouracil, adriamycin, mitoxantrone, 4-O′-te-trahydropyranyladriamycin (THP), vincristine, etoposide and cisplatin were not detectable in the dialysate after 4 h. In some of the experiments cyclophosphamide and bleomycin were detected after 4 h, but not after 2 h. 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) and mitoxantrone were found to permeate the latex membrane within 15 min. The dialysate of the BCNU original drug formulation (3.3 mg/ml) reached a maximum concentration of 0.569 mg/ml; the maximum concentration of mitoxantrone was three orders of magnitude lower.
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