Abstract
This chapter discusses the regulation of the cell cycle by somatomedins. The chapter analyzes a group of growth factors that resemble insulin—insulin-like growth factors (ILGFs). The group consists of somatomedins A, nonsuppressible insulinlike activity (that is made up of insulin growth factors one and two, IGF I, IGF II), and multiplication stimulating activity (MSA). The ILGFs may constitute one of the first groups of growth regulators. A range of different culture lines has been evaluated for responses to insulin-like growth factors. In some cases, the cells are stimulated to increase DNA synthesis by a single purified factor whereas, in others, varying combinations are required. The ones responsive to somatomedin C are chondrocytes, frog and rabbit lens epithelium, Sertoli and granulosa cells, fetal liver and limb bud, some blood cell lines, and pituitary tumor cells. In the lens, the migration of epithelial cells and the fashioning of fibers from these cells are stopped in the absence of somatomedin-like molecules.
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