Abstract
Daily convulsive seizures were elicited in rats by stimulation through electrodes implanted in the hypothalamus or forebrain. Seizure thresholds fell approximately 20% after a single seizure, and by more than 50% after another ten. The fall in threshold appeared to be permanent, cumulative, specific to electrical stimulation, and restricted to the region of the electrodes. It did not depend on erosion of metallic particles from the electrodes, or on reversible tissue changes. Thresholds were not affected by seizures induced either by inhalation of flurothyl (Indoklon), nor by electrical stimulation of remote parts of the brain. It was concluded that the changes in seizure threshold depended on local changes brought about by the passage of electrical current through the affected area.
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