Abstract
The health risks and side effects of fluoroquinolone use include the risk of tendon rupture and myasthenia gravis exacerbation, and on August 15, 2013, the Food and Drug Administration updated its warning to include the risk of permanent peripheral neuropathy. We present a case of fluoroquinolone-induced peripheral neuropathy in a patient treated for clinically diagnosed urinary tract infection with ciprofloxacin antibiotic.
Highlights
While there has been success in recent years in decreasing the numbers of unnecessary antibiotic administrations,[1] still rampant in medical practice is the inappropriate use of antibiotics
Fluoroquinolones administration is no different. These bactericidal agents are capable of central nervous system (CNS) penetration,[2] with an impressive treatment profile that includes an enhanced spectrum of activity, high oral bioavailability, high serum drug concentration that parallels that of intravenous drug administration, and rapid mechanism of action
Reports in recent years of the adverse drug events of these drugs are on the rise, with an overrepresentation of common antibiotic complaints, including diarrhea, nausea, and headache that occur at rates higher than most other antimicrobials on the market,[3] but there is mounting evidence suggesting the potential for longterm adverse peripheral nervous system (PNS) effects from fluoroquinolone usage
Summary
While there has been success in recent years in decreasing the numbers of unnecessary antibiotic administrations,[1] still rampant in medical practice is the inappropriate use of antibiotics. Her blood work and further questioning could provide no new medical etiology for her symptoms, and so the patient was subsequently sent for complete neurological workup.
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